Penn Herb Wellness Guide
SAMe
S-adenosyl-l-methionine (SAMe) is an important biological agent in the human body, participating in over 40 essential biochemical reactions.
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement,little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
This supplement has been used in connection with the following health conditions:
| Used for | Amount | Why |
|---|---|---|
Liver Cirrhosis | 1,200 mg daily |  [3 stars] Taking SAMe may improve liver function, bile flow, and survival. |
Osteoarthritis | 1200 mg daily | [3 stars] SAMe has anti-inflammatory, pain-relieving, and tissue-healing properties that may help protect the health of joints and reduce osteoarthritis symptoms. |
Depression | 1,600 mg daily |  [2 stars] SAMe appears to raise levels of dopamine, an important neurotransmitter in mood regulation. |
Fibromyalgia | 800 mg daily | [2 stars] Supplementing with SAMe may increase serotonin levels in the blood and help relieve symptoms. |
Hepatitis and Cholestasis | 1,600 mg daily | [2 stars] Supplementing with SAMe may help resolve blocked bile flow. |
Pregnancy and Postpartum Support and Cholestasis | Refer to label instructions | [2 stars] SAMe (S-adenosylmethionine) supplementation has been shown to aid in the resolution of blocked bile flow (cholestasis), an occasional complication of pregnancy.1, 2 |
Bipolar Disorder | Refer to label instructions |  [1 star] SAMe is an amino acid that has an impact on serotonin levels, it has shown significant antidepressant effects in clinical trials. |
Male Infertility | Refer to label instructions | [1 star] Preliminary research suggests that oral SAMe may also increase sperm activity in infertile men. |
Migraine Headache | Refer to label instructions | [1 star] Preliminary research suggests that supplementing with SAMe may reduce symptoms for some migraine sufferers. |
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.