Penn Herb Wellness Guide
Pregnenolone
Side Effects
Due to its antagonistic effects on the GABA receptor in the central nervous system, supplementation with pregnenolone could cause problems in people with a history of seizures. Pregnenolone supplementation may increase the levels of progesterone and DHEA in the body and possibly the levels of other hormones (testosterone and estradiol). In theory, pregnenolone could cause disturbances in the endocrine system, which may manifest as changes in the menstrual cycle or the development or aggravation of hormone sensitive diseases (including breast and prostate cancer). The side effects and interactions with other therapies are currently unknown.
Copyright 2025 TraceGains, Inc. All rights reserved.
Learn more about TraceGains, the company.
The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.