Penn Herb Wellness Guide
Pregnenolone
How to Use It
Pregnenolone is generally available in amounts of 10 to 30 mg. It is not known what an appropriate intake is for humans or whether the benefits of taking this hormone outweigh the risks.
Where to Find It
The cells of both the adrenal gland and the central nervous system synthesize pregnenolone. Human studies show there are much higher concentrations of pregnenolone in the nervous tissue, than in the bloodstream.2 Animal studies indicate the concentration of pregnenolone in the brain is ten-fold higher than that of other stress-related hormones (including DHEA).3 Pregnenolone is present in the blood as both free pregnenolone and a more stable form, pregnenolone-sulfate.
Possible Deficiencies
Since it is not an essential nutrient, pregnenolone is not associated with a deficiency state.
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.