Penn Herb Wellness Guide
Restless Legs Syndrome
- Reliable and relatively consistent scientific data showing a substantial health benefit.
- Contradictory, insufficient, or preliminary studies suggesting a health benefit or minimal health benefit.
- For an herb, supported by traditional use but minimal or no scientific evidence. For a supplement, little scientific support.
Our proprietary “Star-Rating” system was developed to help you easily understand the amount of scientific support behind each supplement in relation to a specific health condition. While there is no way to predict whether a vitamin, mineral, or herb will successfully treat or prevent associated health conditions, our unique ratings tell you how well these supplements are understood by some in the medical community, and whether studies have found them to be effective for other people.
For over a decade, our team has combed through thousands of research articles published in reputable journals. To help you make educated decisions, and to better understand controversial or confusing supplements, our medical experts have digested the science into these three easy-to-follow ratings. We hope this provides you with a helpful resource to make informed decisions towards your health and well-being.
| Supplement | Amount | Why |
|---|---|---|
Iron (Iron-Deficiency Anemia) | Consult a qualified healthcare practitioner |  [2 stars] When iron deficiency is the cause of restless leg syndrome, supplementing with iron may reduce the severity of the symptoms. |
Folic Acid | Refer to label instructions |  [1 star] People with familial restless leg syndrome appear to have an unusually high requirement for folic acid. Supplementing with folic acid may help relieve uncomfortable sensations. |
L-Tryptophan | 1 to 2 grams at bedtime | [1 star] Preliminary research has shown some benefit reducing symptoms of restless legs syndrome and the insomnia that often accompanies it. |
Magnesium | Refer to label instructions | [1 star] Supplementing with magnesium may help relieve insomnia in people with restless leg syndrome. |
Vitamin D | Refer to label instructions | [1 star] In one small study, in people with a vitamin D blood level below 20 ng/ml, vitamin D supplementation decreased the severity of restless legs syndrome. |
Vitamin E | Refer to label instructions | [1 star] In one study, supplementing with vitamin E produced complete relief in seven out of nine people with restless leg syndrome. |
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The information presented by TraceGains is for informational purposes only. It is based on scientific studies (human, animal, or in vitro), clinical experience, or traditional usage as cited in each article. The results reported may not necessarily occur in all individuals. Self-treatment is not recommended for life-threatening conditions that require medical treatment under a doctor's care. For many of the conditions discussed, treatment with prescription or over the counter medication is also available. Consult your doctor, practitioner, and/or pharmacist for any health problem and before using any supplements or before making any changes in prescribed medications. Information expires December 2025.