Malabsorption is a broad term used to describe the inability to absorb nutrients through the gut lining into the bloodstream.

Malabsorption is not a disease by itself, but rather the result of some other condition that is present. The small intestine (also called the small bowel) is typically involved in malabsorption, since the majority of nutrients are absorbed there. Malabsorption may affect one or more of the many nutrients present in the diet, including protein, fat, carbohydrate, vitamins, and minerals.

There are over 100 different conditions that can lead to problems in absorbing food, most of which are rare. The degree of malabsorption depends on the type of underlying condition and the extent to which it has affected the gut. Some of the more common malabsorption syndromes are due to bacterial or parasitic infections, Crohn’s disease, celiac disease, ulcerative colitis, liver disease (including cirrhosis, hepatitis, and gallstones), cystic fibrosis, lactose intolerance, chronic pancreatitis, specific medications that affect the intestines, or surgery of the stomach or bowels. The four conditions that most often lead to malabsorption in the United States are lactose intolerance, celiac disease, Crohn’s disease, and chronic pancreatitis.¹

Malabsorption may also occur when certain minerals present in the digestive tract in large amounts prevent adequate absorption of other minerals that are present in relatively small amounts. Minerals that may have this type of interaction include calcium, copper, iron, magnesium, manganese, and zinc.